The long-term effects of deferred care during the COVID-19 pandemic likely will bear out in adverse health outcomes for years. The impact of social isolation on individual mental health and psychosocial well-being is one indirect consequence of the pandemic that has garnered the attention of health care providers, policymakers and media. Dramatic differences in the volumes of all hospital-based service lines impose difficulty in comparing trends between 2019 and 2020, particularly during the early days of the pandemic and coinciding “Stay Home Missouri” executive order. However, evaluating daily hospital emergency department visits for suicide attempt or ideation as a percent of total visits underscores concerns surrounding the pandemic’s indirect effects on mental health. While it is critically important for Missourians to continue practicing hand hygiene, masking and physical distancing, it is equally important that they safely maintain social connectedness.