The daily number of patients hospitalized for COVID-19 is less than one-fourth of the volumes experienced during peak levels in late December 2020. For the first time since last July, on April 3, Missouri hospitals reported just under 700 patients currently hospitalized with confirmed or suspected COVID-19. As a percent of peak surge levels, the Northwest and Central Regions have experienced the largest relative decreases with 93% and 89% reductions, respectively. The largest absolute decreases have occurred in the state’s two largest metropolitan regions of St. Louis and Kansas City, where hospitals now are treating 843 and 514 fewer COVID-19 patients each day compared to peak levels, respectively. Statewide, Missouri hospitals are treating 2,163 fewer COVID-19 patients each day in early April compared to late December. For context, 2,000 COVID-19 patients account for more than 15,000 inpatient bed days on average.